abstract：CONTEXT:Treatment for lower urinary tract symptoms resulting from benign prostatic hyperplasia (BPH) is varied, and significant side effects, particularly concerning sexual function, affect uptake. The prostatic urethral lift (PUL) procedure is a recent addition to the armamentarium for BPH treatment, with independent ...

journal_title：European urology

authors： Perera M,Roberts MJ,Doi SA,Bolton D

更新日期：2015-04-01 00:00:00

abstract：CONTEXT:Clinical data supporting the use of targeted agents for the treatment of metastatic renal cell carcinoma (RCC) are based predominantly on patients with clear cell histology. Little is known about the efficacy of these drugs in non-clear cell variants. OBJECTIVE:To evaluate the efficacy of different clear cell ...

journal_title：European urology

authors： Vera-Badillo FE,Templeton AJ,Duran I,Ocana A,de Gouveia P,Aneja P,Knox JJ,Tannock IF,Escudier B,Amir E

更新日期：2015-04-01 00:00:00

abstract：:Enhanced survival and therapeutic choices for men with prostate cancer mandate the evaluation of the "quality of survival". An exciting series of local, national and international health outcome improvement initiatives offer the enticing prospect of assessing and improving this. ...

journal_title：European urology

authors： Glaser AW,Corner JL

更新日期：2015-03-01 00:00:00

abstract：CONTEXT:Robot-assisted surgery is increasingly used for radical cystectomy (RC) and urinary reconstruction. Sufficient data have accumulated to allow evidence-based consensus on key issues such as perioperative management, comparative effectiveness on surgical complications, and oncologic short- to midterm outcomes. O...

journal_title：European urology

authors： Wilson TG,Guru K,Rosen RC,Wiklund P,Annerstedt M,Bochner BH,Chan KG,Montorsi F,Mottrie A,Murphy D,Novara G,Peabody JO,Palou Redorta J,Skinner EC,Thalmann G,Stenzl A,Yuh B,Catto J,Pasadena Consensus Panel.

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The efficacy of neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (BCa) was established primarily with methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC), with complete response rates (pT0) as high as 38%. However, because of the comparable efficacy with better tolerability of gemci...

journal_title：European urology

authors： Zargar H,Espiritu PN,Fairey AS,Mertens LS,Dinney CP,Mir MC,Krabbe LM,Cookson MS,Jacobsen NE,Gandhi NM,Griffin J,Montgomery JS,Vasdev N,Yu EY,Youssef D,Xylinas E,Campain NJ,Kassouf W,Dall'Era MA,Seah JA,Ercole CE,

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Partial nephrectomy (PN) is a preferred treatment for cT1 renal masses, whereas thermal ablation represents an alternative nephron-sparing option, albeit with higher reported rates of recurrence. OBJECTIVE:To review our experience with PN, percutaneous radiofrequency ablation (RFA), and percutaneous cryoabl...

journal_title：European urology

authors： Thompson RH,Atwell T,Schmit G,Lohse CM,Kurup AN,Weisbrod A,Psutka SP,Stewart SB,Callstrom MR,Cheville JC,Boorjian SA,Leibovich BC

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Pretreatment tables for the prediction of pathologic stage have been published and validated for localized prostate cancer (PCa). No such tables are available for locally advanced (cT3a) PCa. OBJECTIVE:To construct tables predicting pathologic outcome after radical prostatectomy (RP) for patients with cT3a ...

journal_title：European urology

authors： Joniau S,Spahn M,Briganti A,Gandaglia G,Tombal B,Tosco L,Marchioro G,Hsu CY,Walz J,Kneitz B,Bader P,Frohneberg D,Tizzani A,Graefen M,van Cangh P,Karnes RJ,Montorsi F,van Poppel H,Gontero P,European Multicenter Prost

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:A need remains for new therapeutic approaches for men with advanced prostate cancer, particularly earlier in the disease course. OBJECTIVE:To assess the ability of an oral selective estrogen receptor α agonist (GTx-758) to lower testosterone concentrations compared with leuprolide while minimizing estrogen ...

journal_title：European urology

authors： Yu EY,Getzenberg RH,Coss CC,Gittelman MM,Keane T,Tutrone R,Belkoff L,Given R,Bass J,Chu F,Gambla M,Gaylis F,Bailen J,Hancock ML,Smith J,Dalton JT,Steiner MS

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Despite the documented survival benefit conferred by neoadjuvant (NAC) and adjuvant chemotherapy (AC), there has been a slow adoption of guideline recommendations for the use of perioperative chemotherapy (POC) in patients with muscle-invasive bladder cancer (MIBC). OBJECTIVE:To evaluate temporal trends in ...

journal_title：European urology

authors： Reardon ZD,Patel SG,Zaid HB,Stimson CJ,Resnick MJ,Keegan KA,Barocas DA,Chang SS,Cookson MS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Active surveillance (AS) has been proposed as an effective strategy to reduce overtreatment among men with lower risk prostate cancers. However, historical rates of initial surveillance are low (4-20%), and little is known about its application among community-based urology practices. OBJECTIVE:To describe ...

journal_title：European urology

authors： Womble PR,Montie JE,Ye Z,Linsell SM,Lane BR,Miller DC,Michigan Urological Surgery Improvement Collaborative.

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The idea of performing a laparoscopic procedure through a single abdominal incision was conceived with the aim of expediting postoperative recovery. OBJECTIVE:To determine the clinical feasibility and safety of single-port urologic procedures by using a novel robotic surgical system. DESIGN, SETTING, AND P...

journal_title：European urology

authors： Kaouk JH,Haber GP,Autorino R,Crouzet S,Ouzzane A,Flamand V,Villers A

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Molecular profiling of individual cancers is key to personalised medicine. While sequencing technologies have required stringent sample collection and handling, recent technical advances offer sequencing from tissues collected in routine practice and tissues already stored in archives. In this paper, we esta...

journal_title：European urology

authors： Liu Y,Noon AP,Aguiar Cabeza E,Shen J,Kuk C,Ilczynski C,Ni R,Sukhu B,Chan K,Barbosa-Morais NL,Hermanns T,Blencowe BJ,Azad A,van der Kwast TH,Catto JW,Zlotta AR,Wrana JL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Previous studies have shown a modest impact of tyrosine kinase inhibitors on primary renal tumors. Those studies were mostly retrospective or heterogeneous in their eligibility criteria with regard to histology, disease stage, duration of therapy, and time off therapy prior to surgery. OBJECTIVE:To prospect...

journal_title：European urology

authors： Karam JA,Devine CE,Urbauer DL,Lozano M,Maity T,Ahrar K,Tamboli P,Tannir NM,Wood CG

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The contact surface area (CSA) of a tumor with adjacent renal parenchyma may determine the complexity and thus the perioperative outcomes of partial nephrectomy (PN). OBJECTIVE:We devised a novel imaging parameter, renal tumor CSA, and correlate it with perioperative outcomes in patients undergoing PN. DES...

journal_title：European urology

authors： Leslie S,Gill IS,de Castro Abreu AL,Rahmanuddin S,Gill KS,Nguyen M,Berger AK,Goh AC,Cai J,Duddalwar VA,Aron M,Desai MM

更新日期：2014-11-01 00:00:00

abstract：:In the examination of >3000 radical prostatectomy specimens and their seminal vesicles (SVs), we came across a unique case of an intraepithelial abnormality in preexisting ducts and acini in the left SV of a 73-yr-old patient with prostatic adenocarcinoma. At low magnification, the epithelial lining was thicker than t...

journal_title：European urology

authors： Montironi R,Lopez-Beltran A,Cheng L,Galosi AB,Montorsi F,Scarpelli M

更新日期：2014-10-01 00:00:00

abstract：:An alternative to conventional laparoscopy when looking for virtually scarless surgery is mini-laparoscopy, a reproducible technique that preserves the triangulation concept. A drawback of this approach is the poor image quality provided by mini-scopes. The introduction of the SPIEs technology, a novel endoscopic came...

journal_title：European urology

authors： Porpiglia F,Bertolo R,Amparore D,Cattaneo G,Fiori C

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Bone metastases (BMs) are frequently present in patients with metastatic renal cell carcinoma (mRCC) and cause significant morbidity. OBJECTIVE:The purpose of this analysis was to assess the impact of BMs and bisphosphonate therapy (BT) on outcomes in mRCC. DESIGN, SETTING, AND PARTICIPANTS:We conducted a ...

journal_title：European urology

authors： McKay RR,Lin X,Perkins JJ,Heng DY,Simantov R,Choueiri TK

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Many men (21-52%) are reported to have no cancer on the second, also known as the confirmatory, biopsy (B2) for prostate cancer active surveillance (AS). If these men had a reduced risk of pathologic progression, particularly grade related, the intensity of their follow-up could be decreased. OBJECTIVE:To i...

journal_title：European urology

authors： Wong LM,Alibhai SM,Trottier G,Timilshina N,Van der Kwast T,Zlotta A,Lawrentschuk N,Kulkarni G,Hamilton R,Ferrara S,Margel D,Trachtenberg J,Jewett MA,Toi A,Evans A,Fleshner NE,Finelli A

更新日期：2014-09-01 00:00:00

abstract：:The advantages and disadvantages of two different methods of analyzing the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial with respect to the effect of prostate-specific antigen (PSA) screening on prostate cancer (PCa) mortality (ie, disease-specific mortality analysis and excess mortality an...

journal_title：European urology

authors： Zappa M,Puliti D,Hugosson J,Schröder FH,van Leeuwen PJ,Kranse R,Auvinen A,Carlsson S,Kwiatkowski M,Nelen V,Paez Borda A,Roobol MJ,Villers A

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Despite the common use of urinary diaries to assess lower urinary tract symptoms (LUTS), a standardised validated diary does not exist. OBJECTIVE:To develop a validated urinary diary, using the psychometric validation protocol used in previous International Consultation on Incontinence Questionnaire (ICIQ) ...

journal_title：European urology

authors： Bright E,Cotterill N,Drake M,Abrams P

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined. OBJECTIVE:To review the impact of radical prostatectomy (RP) and pelvic lymph node dissection (PLND), possibly in conjunction with a multimodal approach usi...

journal_title：European urology

authors： Gakis G,Boorjian SA,Briganti A,Joniau S,Karazanashvili G,Karnes RJ,Mattei A,Shariat SF,Stenzl A,Wirth M,Stief CG

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Upper tract urothelial carcinoma (UTUC) is a clinically heterogeneous disease that lacks high-quality trials that provide definitive prognostic markers. Insulin-like growth factor messenger RNA binding protein 3 (IMP3) has been associated with outcomes in urothelial carcinoma of the bladder but was not yet s...

journal_title：European urology

authors： Lee DJ,Xylinas E,Rieken M,Khani F,Klatte T,Wood CG,Karam JA,Weizer AZ,Raman JD,Remzi M,Guo CC,Rioux-Leclercq N,Haitel A,Bolenz C,Bensalah K,Sagalowsky AI,Montorsi F,Lotan Y,Shariat SF,Robinson BD,Margulis V

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:To determine the anatomic extent of pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients at the time of radical prostatectomy (RP), knowledge about the topography of lymph node (LN) metastases is required. OBJECTIVE:Because small-volume LN metastases may be missed by standard histopathologi...

journal_title：European urology

authors： Heck MM,Retz M,Bandur M,Souchay M,Vitzthum E,Weirich G,Mollenhauer M,Schuster T,Autenrieth M,Kübler H,Maurer T,Thalgott M,Herkommer K,Gschwend JE,Nawroth R

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:The role of adjuvant chemotherapy remains poorly defined for the management of muscle-invasive bladder cancer (MIBC). The last meta-analysis evaluating adjuvant chemotherapy, conducted in 2005, had limited power to fully support its use. OBJECTIVE:To update the current evidence of the benefit of postoperative ...

journal_title：European urology

authors： Leow JJ,Martin-Doyle W,Rajagopal PS,Patel CG,Anderson EM,Rothman AT,Cote RJ,Urun Y,Chang SL,Choueiri TK,Bellmunt J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Midurethral slings have become the most preferred surgical treatment for female urinary incontinence. OBJECTIVE:To compare the efficacy and safety of two midurethral sling procedures with a different technique of sling insertion 5 yr after intervention. DESIGN, SETTING, AND PARTICIPANTS:Multicenter randomi...

journal_title：European urology

authors： Laurikainen E,Valpas A,Aukee P,Kivelä A,Rinne K,Takala T,Nilsson CG

更新日期：2014-06-01 00:00:00

abstract：:Recent work from surgeons in Europe and the United States has provided both the motivation, and a blueprint, for implementing peer assessments of technical skill as a robust and practical strategy for evaluating and ultimately improving technical expertise with radical prostatectomy. ...

journal_title：European urology

authors： Miller DC,Birkmeyer JD

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Perineural invasion is discussed as a significant route of extraprostatic extension in prostate cancer (PCa). Recent in vitro studies suggested a complex mechanism of neuroepithelial interaction. OBJECTIVE:The present study was intended to investigate whether the concept of neuroepithelial interaction can b...

journal_title：European urology

authors： Bründl J,Schneider S,Weber F,Zeman F,Wieland WF,Ganzer R

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is associated with decreased insulin sensitivity and increased diabetes risk among nondiabetic men. Few data are available about the effects of ADT on diabetes control among men with diabetes. OBJECTIVE:We examined care for men who had diabetes at...

journal_title：European urology

authors： Keating NL,Liu PH,O'Malley AJ,Freedland SJ,Smith MR

更新日期：2014-04-01 00:00:00

abstract：CONTEXT:Overactive bladder (OAB) treatment guidelines recommend antimuscarinics as first-line pharmacologic therapy. Mirabegron is a first-in-class β3-adrenoceptor agonist licensed for the treatment of OAB and has shown to be well tolerated and effective in the treatment of OAB symptoms. OBJECTIVE:To assess the relativ...

journal_title：European urology

authors： Maman K,Aballea S,Nazir J,Desroziers K,Neine ME,Siddiqui E,Odeyemi I,Hakimi Z

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Near-infrared fluorescence (NIRF) imaging is a technology with emerging applications in urologic surgery. OBJECTIVE:To describe surgical techniques and provide clinical outcomes for robotic partial nephrectomy (RPN) with selective clamping and robotic upper urinary tract reconstruction featuring novel appli...

journal_title：European urology

authors： Bjurlin MA,Gan M,McClintock TR,Volpe A,Borofsky MS,Mottrie A,Stifelman MD

更新日期：2014-04-01 00:00:00

abstract：:A randomised trial of robotic and open prostatectomy commenced in October 2010 and is progressing well. Clinical and quality of life outcomes together with economic costs to individuals and the health service are being examined critically to compare outcomes. ...

journal_title：European urology

authors： Gardiner RA,Coughlin GD,Yaxley JW,Dunglison NT,Occhipinti S,Younie SJ,Carter RC,Williams SG,Medcraft RJ,Samaratunga HM,Perry-Keene JL,Payton DJ,Lavin MF,Chambers SK

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Androgen deprivation therapy (ADT) is associated with increased cardiovascular morbidity. OBJECTIVE:To determine whether cardiovascular morbidity differs following initiation of gonadotropin-releasing hormone (GnRH) agonists compared with an antagonist. DESIGN, SETTING, AND PARTICIPANTS:Pooled data from si...

journal_title：European urology

authors： Albertsen PC,Klotz L,Tombal B,Grady J,Olesen TK,Nilsson J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Significant cancer in contralateral sides of the prostate that was missed on prostate biopsy (PBx) is a concern in hemiablative focal therapy (FT) of prostate cancer (PCa). However, extended PBx, a common diagnostic procedure, has a limited predictive ability for lobes without significant cancer. OBJECTIVE:...

journal_title：European urology

authors： Matsuoka Y,Numao N,Saito K,Tanaka H,Kumagai J,Yoshida S,Koga F,Masuda H,Kawakami S,Fujii Y,Kihara K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The presence of lymph node metastasis (LNM) at radical prostatectomy (RP) is associated with poor outcome, and optimal treatment remains undefined. An understanding of the natural history of node-positive prostate cancer (PCa) and identifying prognostic factors is needed. OBJECTIVE:To assess outcomes for pa...

journal_title：European urology

authors： Touijer KA,Mazzola CR,Sjoberg DD,Scardino PT,Eastham JA

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:Controversy remains over whether adrenalectomy and lymph node dissection (LND) should be performed concomitantly with radical nephrectomy (RN) for locally advanced renal cell carcinoma (RCC) cT3-T4N0M0. OBJECTIVE:To systematically review all relevant literature comparing oncologic, perioperative, and quality-o...

journal_title：European urology

authors： Bekema HJ,MacLennan S,Imamura M,Lam TB,Stewart F,Scott N,MacLennan G,McClinton S,Griffiths TR,Skolarikos A,MacLennan SJ,Sylvester R,Ljungberg B,N'Dow J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Primary culture and animal and cell-line models of prostate and bladder development have limitations in describing human biology, and novel strategies that describe the full spectrum of differentiation from foetal through to ageing tissue are required. Recent advances in biology demonstrate that direct repro...

journal_title：European urology

authors： Moad M,Pal D,Hepburn AC,Williamson SC,Wilson L,Lako M,Armstrong L,Hayward SW,Franco OE,Cates JM,Fordham SE,Przyborski S,Carr-Wilkinson J,Robson CN,Heer R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Data describing urinary health in elderly, community-dwelling prostate cancer (PCa) survivors are limited. OBJECTIVE:To elucidate the prevalence of lower urinary tract symptoms, urinary bother, and incontinence in elderly PCa survivors compared with peers without PCa. DESIGN, SETTING, AND PARTICIPANTS:A cr...

journal_title：European urology

authors： Kopp RP,Marshall LM,Wang PY,Bauer DC,Barrett-Connor E,Parsons JK,Osteoporotic Fractures in Men MrOS Research Group.

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Retroperitoneal lymph node dissection (RPLND) is indicated after chemotherapy in case of radiologic incomplete remission or teratomatous elements in orchiectomy specimens. Open RPLND is associated with considerable morbidity, but technical difficulty of postchemotherapy laparoscopic RPLND (L-RPLND) can be si...

journal_title：European urology

authors： Steiner H,Leonhartsberger N,Stoehr B,Peschel R,Pichler R

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The survival impact of metastasectomy for metastatic renal cell carcinoma (mRCC) is still an active research field, particularly in the multimodal/targeted therapy era. OBJECTIVE:To determine the survival impact of clinical prognostic factors and their application to stratification of patients according to ...

journal_title：European urology

authors： Tosco L,Van Poppel H,Frea B,Gregoraci G,Joniau S

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Eraser, a 1318-nm diode laser, has been used for 15 yr for resection of lung metastases. It was recently introduced in urology for small kidney tumors and for the treatment of benign prostatic obstruction. OBJECTIVE:To demonstrate on video our technique of Eraser laser enucleation of the prostate (ELEP) and...

journal_title：European urology

authors： Hruby S,Sieberer M,Schätz T,Jones N,Zimmermann R,Janetschek G,Lusuardi L

更新日期：2013-02-01 00:00:00